林厚文主任藥師
上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院藥劑科
職 稱：主任藥師 職 務(wù)：藥學(xué)部主任 院 區(qū)：東院 科 室：藥劑科 醫(yī)療專長：從事我國遠(yuǎn)海西沙群島的海洋底棲動(dòng)物海綿及其共生微生物藥源分子的發(fā)現(xiàn)、海洋生物功能分子的規(guī)模化制備、結(jié)構(gòu)優(yōu)化、生物活性及作用機(jī)制研究。闡明了中國遠(yuǎn)海西沙海域海綿資源的化學(xué)結(jié)構(gòu)多樣性及其功能特點(diǎn)。 教育經(jīng)歷1995.09?1998.12 沈陽藥科大學(xué)：師從姚新生院士和易楊華教授，從事海洋生物總合草苔蟲抗腫瘤活性成分的分離篩選，獲理學(xué)博士學(xué)位 日本神奈川大學(xué)：博士其間在日本神奈川大學(xué)釜野德明小組研修天然藥物抗腫瘤活性物質(zhì)的活性篩選和分離鑒定 1989.09?1992.07 第二軍醫(yī)大學(xué)藥學(xué)院 碩士 研究常用中藥免疫調(diào)節(jié)活性成分和作用機(jī)理 1985.09?1989.07 第二軍醫(yī)大學(xué)藥學(xué)院 學(xué)士 學(xué)術(shù)職務(wù) 上海交通大學(xué)醫(yī)學(xué)院海洋藥物重點(diǎn)實(shí)驗(yàn)室主任，癌基因與相關(guān)基因國家重點(diǎn)實(shí)驗(yàn)室PI;國家杰出青年科學(xué)基金、上海市優(yōu)秀學(xué)科帶頭人、上海市科技啟明星獲得者。兼任中國海洋生物化學(xué)與分子生物學(xué)分會(huì)副理事長，上海市藥學(xué)會(huì)常務(wù)理事，上海市海洋湖沼學(xué)會(huì)常務(wù)理事，上海市海洋藥物專業(yè)委員會(huì)主任委員。 論文著作1. Piao, S.J., Jiao, W.H., Yang, F., Yi, Y.H., Di, Y.T., Han, B.N.,* Lin, H.W.* New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne. Mar. Drugs, 2014, 12(7): 4096-4109 2. Jiao, W.H., Xu, T.T., Yu, H.B., Mu, F.R., Li, J, Li, Y.S., Yang, F., Han,B.N., Lin, H.W.* Dysidaminones A-M, Cytotoxic and NF-κB InhibitorySesquiterpeneAminoquinones from the South China SeaSponge DysideafragilisRSC Advances, 4, 9236–9246(IF = 2.562) 3. Gan, J.H., Xu, C.H., Yu, H.B., Lin, H.W.*Zhou, Q., Sun, S.Q.* Rapid Discrimination of China Sponges by Tri-step Infrared Spectroscopy: A Preliminary Study. Journal of Molecular Structure，2014, 1069, 147–151 4. Jiao, W.H., Xu, T.T., Yu, H.B., Chen, G.D., Huang, X.J., Yang, F, Li, Y.S., Han, B.N., Liu, X.Y.* Lin, H.W. * Dysideanones A?C, Unusual Sesquiterpene Quinones from the South China Sea Sponge Dysideaavara. Journal of Natural Products, 2014, 77 (2), 346–350 5. Piao, S.J., Song, Y.L., Jiao, W.H., Yang, F., Liu, X.F., Chen, W.S., Han, B.N., Lin, H.W. * Hippolachnin A, a New AntifungalPolyketide from the South China SeaSponge Hippospongialachne. Organic Letters, 2013, 15 (14): 3526-3529 (IF = 6.142) (IF = 6.142) 6. Yan, M., Zhu, Y., Zhang, H.J., Jiao, W.H., Han, B.N., Liu, Z.X., Qiu, F. * Chen, W.S., Lin, H.W.* Anti-inflammatory secondary metabolites from the leaves of Rosalaevigata. Bioorganic & Medicinal Chemistry, 2013, 21 (11): 3290–3297 (IF = 2.903) 7. Wang, Y.W., Zhang, J.B., Wang, Q.X., Zhang, T., Yang, Y., Yi, Y.H., Gao, G.X., Dong, H.J., Zhu, H.F., Li, Y., Lin, H.W.* Tang, H.F.* Chen, X.Q.* Bryostatin 5 induces apoptosis in acute monocytic leukemia cells by activating PUMA and caspases. European Journal of Pharmacology, 2013, 718: 340-349(IF=2.592) 8. Yang, F., Ji, R.H., Li, J., Gan, J.H., Lin, H.W.* N-Containing Metabolites from the Marine Sponge Agelasclathrodes. Natural Product Communications. 2013, 8 (12), 1713-1714 (IF = 0.956) 9. Xu, Y., Lang, J.H., Jiao, W.H., Wang, R.P., Peng, Y., Song, S.J.* Zhang, B.H.* Lin, H.W.* Formamido-Diterpenes from the South China Sea SpongeAcanthellacavernosa. Marine Drugs, 2012,10: 1445-1458 (IF = 3.978) 10. Yu, H.B., Liu, X.F., Xu, Y., Gan, J.H., Jiao, W.H., Lin, H.W.* Woodylides A?C, Three New Cytotoxic secoPolyketides from the South China Sea Marine Sponge Plakortis simplex, Marine Drugs, 2012,10: 1027?1036 (IF = 3.978) 11. Liu, X.F.,?Shen, Y.* Yang, F., Jiao, W.H., Zhang, H.J., Yu, H.B., Chen, W.S., Xiao, J.R., Lin, H.W.* Simplexolides A?F and Plakorfuran A, Seven Butyrate Derived Polyketides from the Marine Sponge Plakortis simplex. Tetrahedron, 2012，68: 4635?4640(IF = 2.803) 12. Yang, F., Hamann, M.T., Zou, Y.K., Zhang, M.Y., Gong, X.B., Chen, W.S., Lin, H.W.* Antimicrobial Metabolites from the ParacelIslands sponge Agelasmauritiana. Journal of Natural Products, 2012，75 (4)：774–778(IF = 3.285) 13. Wang, R.P., Lin, H.W.* Li, L.Z., Gao, P.Y., Xu, Y., Song, S.J.*(共同通訊).Monoindole alkaloids from a marine sponge Mycalefibrexilis. Biochemical Systematics and Ecology,2012, 43: 210-213(IF = 1.153) 14. Xu, Y., Song, Y.L., Li, N., Jiao, W.H., Wang, R.P., Peng, Y., Qi, S.H., Song, S.J. * Chen, W.S., Lin, H.W.* Antifouling and cytotoxic constituents from the South China Sea sponge Acanthellaconvernosa: absolute stereostructures of kalihinols M?-T. Tetrahedron, 2012, 68: 2876?2883(IF = 2.803) 15. Han, M.Q., Liu, F., Zhang, F.L., Li, Z.Y. * Lin, H.W.* Bacterial and ArchaealSymbionts in the South China Sea Sponge Phakelliafusca: Community Structure, Relative Abundance and Ammonia-oxidizing Populations, Mar Biotechnol, 2012, 14:701–713(IF =2.739). 16. Jiao, W.H., Huang, X.J., Yang, J.S., Gao, H., Yang, F., Piao, S.J., Li, J., Ye, W.C., Yao, X.S., Chen, W.S., Lin, H.W.* Dysidavarones A-?D, Novel Sesquiterpene Quinones from Marine SpongeDysideaavara. Organic Letters, 2012, 14 (1): 202?205 (IF = 6.142) 17. Liu, X.F., Song, Y.L., Zhang, H.J., Yang, F., Yu, H.B., Jiao, W.H., Piao, S.J., Chen, W.S., Lin, H.W.* Simplextones A and B, Unusual Polyketides from the Marine Sponge Plakortis simplex. Organic Letters, 2011, 13 (12): 3154–3157 (IF = 5.862). 18. Piao, S.J., Zhang, H.J., Lu, H.Y., Yang, F., Jiao, W.H., Yi, Y.H., Chen, W.S., Lin, H.W.* Hippolides A–H, Acyclic Manoalide Derivatives from the Marine Sponge Hippospongialachne. Journal of Natural Products, 2011, 74 (5): 1248-1254 (IF = 3.128). 19. Zeng, N., Shen, Y.* Li, L.Z., Jiao, W.H., Gao, P.Y., Song, S.J., Chen, W.S., Lin, H.W.* Anti-inflammatory Triterpenes from the Leaves of Rosalaevigata.Journal of Natural Products, 2011, 74 (4): 732–738 (IF = 3.128). 20. Yang, F., Chen, J.T., Piao, S.J., Chen, W.S., Lin, H.W.* New cytotoxic oxygenated sterols from marine bryozoan Bugulaneritina. Natural Product Research,2011, 25(16):1505-11(IF=0.81). 21. Chu, D., Peng, C.S., Ding, B., Liu, F., Zhang, F.L., Lin, H.W.* Li, Z.Y.* Biological active metabolite cyclo (L-Trp-L-Phe) produced by South China Sea sponge Holoxea sp. Associated fungus Aspergillusversicolor strain TS08. Bioprocess and Biosystems Engineering, 2010, 34 (2):223-9(IF=1.823). 22. Zhang, H.J., Yi, Y.H., Yang, G.J., Hu, M.Y., Cao, G.D., Yang, F., Lin, H.W.* Proline-Containing Cyclopeptides from the Marine Sponge Phakelliafusca. Journal of Natural Products, 2010,73 (4)：650–655(IF = 3.159). 23. Tang, H., Wang, Z.L., Cheng, P., Piao, S.J., Chen, W.S., Lin, H.W.* Hai-Feng Tang. Steroids from the marine bryozoan Bugulaneritina. Chemistry of Natural Compounds, 2010, 46 (3): 330-332(IF=0.572). 24. Zhang, H.J., Yi, Y.H., Lin, H.W.* Oxygenated 4-Methylene Sterols from the South China Sea Sponge Theonellaswinhoei. Helvetica ChimicaActa,2010, 93, 1120-1126(IF=1.435). 25. Gao, P.Y., Li, L.Z., Peng, Y., Piao, S.J., Zeng, N., Lin, H.W.* Song, S.J.* Triterpenes from fruits of Rosalaevigata. Biochemical Systematics and Ecology, 2010, 38 (3)：457–459(IF=1.131). 26. Yang, F., Zhang, H.J., Zhang, Y.Y., Chen, W.S., Yuan, H.L.* Lin, H.W.* A Hepatitis B Virus Inhibitory Neolignan from Herpetospermumcaudigerum.Chem Pharm Bull, 2010, 58 (3): 402-404(IF=1.698). 27. Zhang, H.J., Yi, Y.H., Yang, F., Chen, W.S., Lin, H.W.* Sesterterpenes and a New Sterol from the Marine Sponge Phyllospongiafoliascens. Molecules, 2010, 15(2)：834-841(IF=1.738). 28. Tang, H.F.* Cheng, G., Wu, J., Chen, X.L., Zhang, S.Y., Wen, A.D., Lin, H.W.* Cytotoxic asterosaponins capable of promoting polymerization of tubulin from the starfish Culcitanovaeguineae. Journal of Natural Products, 2009, 72 (2): 284-289(IF=3.159). 29. Zhang, H.J., Tang, H.F., Yi, Y.H., Lin, H.W.* ScalaraneSesterterpenes from the Chinese Sponge Phyllospongiafoliascens. Helvetica ChimicaActa, 2009, 29 (4): 762-767(IF=1.435). 30. Yang, F., Zhang, H.J., Liu, X.F., Chen, W.S., Tang, H.F.* Lin, H.W.* Oxygenated steroids from marine bryozoan Biflustragrandicella. Biochemical Systematics and Ecology, 2009, 37: 686-689(IF=1.131). 獲得榮譽(yù) 主持4項(xiàng)國家863課題、3項(xiàng)國家科技重大專項(xiàng)、5項(xiàng)國家自然科學(xué)1金等課題22項(xiàng)。獲“第六屆施維雅青年藥物化學(xué)家獎(jiǎng)”(2003)、“上海藥學(xué)科技二等獎(jiǎng)”(2006)、“中國藥學(xué)科學(xué)技術(shù)二等獎(jiǎng)”(2007)、“上海醫(yī)學(xué)科技二等獎(jiǎng)”(2007)、“中華中醫(yī)藥學(xué)會(huì)科學(xué)技術(shù)二等獎(jiǎng)”(2009)。近五年以通訊作者發(fā)表SCI收錄論文28篇，影響因子5分以上3篇。申請(qǐng)發(fā)明專利18項(xiàng)，其中11項(xiàng)獲專利授權(quán)
闡明了中國遠(yuǎn)海西沙海域海綿資源的化學(xué)結(jié)構(gòu)多樣性及其功能特點(diǎn)。?
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